The First Metabolostasis Conference

Metabolism describes the complex network of reactions that enable organisms to generate the energy and molecules, metabolites, they need to thrive. The paramount role metabolites play across the branches of life, as well as their part in various disorders, has been investigated for decades. Yet, only recently it has been revealed that these life-essential building blocks can form cytotoxic aggregates, similar to those found in neurodegenerative disorders such as Alzheimer’s disease and Parkinson's disease.

This discovery raises elementary questions regarding metabolite homeostasis - "metabolostasis" - mechanisms that maintain metabolites in a soluble, non-aggregative, state. Such quality-control mechanisms must allow the sufficient supply of metabolites on one hand, while strictly monitoring their levels and avoiding aggregation on the other. These mechanisms, we believe, have co-evolved with the metabolites themselves, and originated very early in the evolutionary timeline.

Speakers:

• Lihi Adler-Abramovich; Tel Aviv University

• Valery Andrushchenko; Czech Academy of Sciences

• Thanh Do; University of Tennessee

• Moran Frenkel-Pinter; Hebrew University of Jerusalem

• Ehud Gazit; Tel Aviv University

• Søren W. Gersting; University Medical Center Hamburg-Eppendorf

• Priyanka Joshi; University of California, Berkeley

• Tuomas Knowles; University of Cambridge

• Dana Laor Bar-Yosef; Tel Aviv University

• Davide Levy; Tel Aviv University

• Daniel Otzen; Aarhus University

• Jana Pilátová; Charles University

• Meital Reches; Hebrew University of Jerusalem

• Peter Roy; University of Toronto

• Daniel Segal; Tel Aviv University

• Orna Staretz-Chacham; Soroka University Medical Center

• Tofail Syed; University of Limerick

• Damien Thompson; University of Limerick

• Loren Williams; Georgia Tech

• Chengqian Yuan; Institute of Process Engineering,

• Einat Zalckvar; Weizmann Institute of Science

Organizing Committee:

Dana Laor

Tal Yehuda

Ehud Gazit

Sponsor:

This conference was made possible through the support of a grant from the John Templeton Foundation.

Event Schedule:

9:00AM - 1:00PM EDT

3:00PM - 7:00PM CET

4:00PM - 8:00PM IST

Join Zoom Meeting:

https://tau-ac-il.zoom.us/j/89170619016

Contact:

metabolostasis@gmail.com